Central regulation of food intake, body weight, energy expenditure, and glucose homeostasis

Central regulation of food intake, body weight, energy expenditure, and glucose homeostasis

Michael M. Scott, Yong Xu, Carol F. Elias and Kevin W. Williams* 1 Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, USA 2 Department of Pediatrics, Children’s Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA 3 Department of Molecular and Integrative Physiology, Obstetrics, and Gynecology, The University of Michigan Medical School, Ann Arbor, M...

Extrapancreatic incretin receptors modulate glucose homeostasis, body weight, and energy expenditure.

The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) control glucose homeostasis through well-defined actions on the islet beta cell via stimulation of insulin secretion and preservation and expansion of beta cell mass. We examined the importance of endogenous incretin receptors for control of glucose homeostasis through analysis of Glp1r(...

Leptin and the Regulation of Food Intake and Body Weight.

Central transthyretin acts to decrease food intake and body weight.

Transthyretin (TTR) is a blood and cerebrospinal fluid transporter of thyroxine and retinol. Gene expression profiling revealed an elevation of Ttr expression in the dorsomedial hypothalamus (DMH) of rats with exercise-induced anorexia, implying that central TTR may also play a functional role in modulating food intake and energy balance. To test this hypothesis, we have examined the effects of...

Regulation of food intake and body weight by recombinant proghrelin.

Ghrelin is a 28-amino-acid hormone derived from the endoproteolytic processing of its prehormone proghrelin. Although ghrelin has been reported to regulate food intake and body weight, it is still unknown whether proghrelin exercises any biological function. Here we show that recombinant proghrelin alters food intake and energy metabolism in mice. After intraperitoneal administration of recombi...